Within the area of developing clinical read-out parameters, the SPP2127 will not only develop fMRI protocols and psychophysical retinal testing protocols under direct visualization and compare them in order to quantify and compare therapeutic benefit at the retinal and cortical level, but will explore adaptive optics to describe retinal integration of cells after cell therapy and morphological fate of cones in gene based therapies, will develop new functional read-out parameter for infants and preverbal children in order to have the tools at hand to treat in the future very early disease stages and will develop new functional read-out parameters for patients with ultra-low vision not capable to work with the standard examination tools.

• Which are early morphological read-out parameter that allow to identify retinal regions that profit most from a gene or cell based therapy?
• How can we measure functional benefit in treated areas in patients with very low level residual function?
• How can we measure reliable function in infants and pre-verbal children not capable to comply with conventional examination tools?